Standardization of lyophilized dosage form of dimeric macrocyclic tannin

synthesis and characterization of some macrocyclic schiff bases

ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...

Standardization an a Rp-hplc Method for the Estimation of Aceclofenac in Dosage Form

A rapid and sensitivity RP-HPLC method was proposed for the qualitative and quantitative estimation of Aceclofenac in dosage form. Aceclofenac had been chromatographed on a C18 column with a mobile phase buffer pH 5.0 and Acetonitrile in the ratio of 60:40v/v. The mobile phase was pumped at a flow rate 1ml/min. Etoricoxib was used as internal standard and elutents were monitored at 275nm. The r...

A macrocyclic dimeric diterpene with a C2 symmetry axis.

An unprecedented macrocyclic dimeric diterpene containing a C2 symmetry axis was isolated from Acacia schaffneri . This compound, named schaffnerine, was characterized as (5S,7S,8R,9R,10S,17S,5'S,7'S,8'R,9'R,10'S,17'S)-7,8:7,17':16,17:17,7':7',8':16',17'-hexaepoxy-7,8-seco-7',8'-seco-dicassa-13,13'-diene (1) from its spectroscopic data. Comparison of its experimental vibrational circular dichro...

Thrombin clotting activity measurement and standardization with lyophilized plasma.

Thrombin-induced clotting times were inversely proportional to fibrinogen concentrations within the range of 98 to 2900 nmol/L; these reciprocal velocity measurements had units of seconds per clot. By analogy with classical enzyme kinetics, we defined rectangular hyperbolic parameters where Km(clot) ranged from 0.14 to 0.56 mumol/L and kclot from 0.020 to 0.075 clot per second. Specificity rati...

Sterile Dosage Form